Yes, it is possible. Actually the smaller the margin, the better the ROI.
Example you can easy buy a bit of four and make bread. You can get ROI of 50 to 100% or even more. Retail food have very low barriers to enter. But to make 1,000$ profit for example, you need to sell to about 2,000 clients.
But for example Warren Buffet, he has ROI of 30 – 40%, but the margin is billions , so it is different story.
So re-structure your goal and decide what kind of market you going to go for, the small margin or the large margin?